What question did this study set out to answer?

This research aims to determine the role of thrombosis versus injury in the formation of lipid-rich thromboatherosclerotic lesions in rabbits.

January 1, 1976Thrombosis and Haemostasis

Inhibition of Injury Induced Thromboatherosclerotic Lesions by Anti-Platelet Serum in Rabbits

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Why the study?

Does anti-platelet serum reduce the extent of injury-induced thromboatherosclerotic lesions in rabbits?

Population

35 rabbits maintained on a diet unsupplemented by lipid, with PE 60 polyethylene catheters placed in the…

Comparison

Anti-platelet serum to washed sonicated rabbit… vs No APS in the first experiment; normal sheep…

Design

Preclinical, randomly divided into 2 groups

Follow-up

14 days

Authors

SMSean MooreEast Tennessee State University RFR. J. FriedmanBoston University DSD. P. SingalTulane University

Discussion

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Implication

Severe thrombocytopenia prevents raised lesions post-injury in rabbits; leaves open translation to human atherogenesis prevention.

Key Points

This research aims to determine the role of thrombosis versus injury in the formation of lipid-rich thromboatherosclerotic lesions in rabbits.
35 rabbits underwent aortic catheterization and were divided into control (no APS) and experimental (with APS) groups.
The experimental group received a series of injections of anti-platelet serum for 14 days, while the control group did not.
Lesion extent was measured by assessing the weight of different types of lesions in the aorta.
The mean weight of raised lesions in the control group was 6 to 7 times greater than in the experimental group (P < 0.001).
Platelet counts decreased significantly in the experimental group, with complete prevention of lesions in animals with counts ≤ 1,000 mm3.
Anti-platelet serum was more effective than normal sheep serum in reducing raised lesions.

Structured PICO

Does anti-platelet serum reduce the extent of injury-induced thromboatherosclerotic lesions in rabbits?

Population

35 rabbits maintained on a diet unsupplemented by lipid, with PE 60 polyethylene catheters placed in the aortas via a femoral artery to induce intimal injury.

Intervention

Anti-platelet serum (APS) to washed sonicated rabbit platelets raised in sheep (1.0 ml intravascular injection, followed 8 hours later by 0.5 ml subcutaneous injection, then 0.5 ml subcutaneously daily for 13 days).

Comparator

No APS (18 rabbits) in the first experiment; normal sheep serum (NSS) in a second experiment.

Outcome

Extent of lesions (estimated by weight of raised lesions from photographed and cut-out areas of opened aortas) at 14 days.surrogate

In a rabbit model of catheter-induced intimal injury, severe thrombocytopenia induced by anti-platelet serum almost completely prevented the formation of lipid-rich raised thromboatherosclerotic lesions, highlighting the critical role of thrombosis in atherogenesis.

Cite This Study

Moore et al. (1976) studied this question.

synapsesocial.com/papers/6a6f8570a528af2d65c308b3 https://doi.org/10.1055/s-0038-1647912

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Inhibition of Injury Induced Thromboatherosclerotic Lesions by Anti-Platelet Serum in Rabbits

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Inhibition of Injury Induced Thromboatherosclerotic Lesions by Anti-Platelet Serum in Rabbits

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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