October 1, 1999The Journal of PhysiologyOpen Access

Effects of mutations causing hypokalaemic periodic paralysis on the skeletal muscle L‐type Ca2+ channel expressed in Xenopus laevis oocytes

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Population

Xenopus laevis oocytes expressing a truncated form of the rabbit alpha1S Ca2+ channel subunit with beta1b…

Comparison

Introduction of missense mutations causing… vs Wild-type L-type Ca2+ channels

Design

Preclinical

Authors

JMJames A. MorrillHarvard University SCStephen C. CannonBoston University

Discussion

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Implication

Highlights domain-specific gating defects in HypoPP models; leaves open contribution to human muscle excitability.

Structured PICO

Population

Xenopus laevis oocytes expressing a truncated form of the rabbit alpha1S Ca2+ channel subunit (alpha1SDeltaC) with beta1b, alpha2delta and gamma auxiliary subunits

Intervention

Introduction of missense mutations causing hypokalaemic periodic paralysis (R528H, R1239H, R1239G)

Comparator

Wild-type L-type Ca2+ channels

Outcome

L-type current amplitude and gating properties (activation and steady-state inactivation)surrogate

Mutations causing hypokalaemic periodic paralysis have distinct effects on the gating properties of skeletal muscle L-type Ca2+ channels depending on their domain location.

Cite This Study

Morrill et al. (1999) studied this question.

synapsesocial.com/papers/6a6f86378031ec7bb1dbccd8 https://doi.org/10.1111/j.1469-7793.1999.00321.x

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Effects of mutations causing hypokalaemic periodic paralysis on the skeletal muscle L‐type Ca2+ channel expressed in Xenopus laevis oocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of mutations causing hypokalaemic periodic paralysis on the skeletal muscle L‐type Ca2+ channel expressed in Xenopus laevis oocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider