Perireceptor events in olfaction

Before reaching olfactory receptor neurons, odorant molecules have to cross an aqueous interface: the nasal mucus in vertebrates and the sensillar lymph in insects. Biochemical interactions taking place between odorants and the elements of these phases are called perireceptor events. Main protein constituents of these media, in both insects and vertebrates, are OBPs (odorant-binding proteins). Another class of proteins active in the olfactory perireceptor area includes odorant-degrading enzymes. The structure and the properties of these major proteins, with particular reference to OBPs, are reviewed and their role in olfactory transduction is discussed.