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September 1, 1992Journal of VirologyOpen Access

The C terminus of human immunodeficiency virus type 1 matrix protein is involved in early steps of the virus life cycle

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Population

Human immunodeficiency virus type 1 (HIV-1) and infected cells (in vitro model)

Comparison

Deletion mutations at the C terminus of the… vs Wild-type HIV-1 virions

Design

Preclinical

Authors

XYXiao YuJilin UniversityQYQ C YuFirst Affiliated Hospital of Zhengzhou UniversityTLT H LeeYale University

Discussion

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Overview

Matrix C-terminus required for HIV entry; leaves open therapeutic targeting in humans.

Structured PICO

P
Population
Human immunodeficiency virus type 1 (HIV-1) and infected cells (in vitro model)
I
Intervention
Deletion mutations at the C terminus of the matrix (MA) protein generated by site-directed mutagenesis
C
Comparator
Wild-type HIV-1 virions
O
Outcome
Virus infectivity and steps of the virus life cycle (synthesis and processing of Gag polyprotein, assembly and release, viral DNA synthesis postinfection)surrogate

The C terminus of the HIV-1 matrix protein plays an important role in early steps of the virus life cycle, specifically virus entry.

Cite This Study

Yu et al. (1992) studied this question.

synapsesocial.com/papers/6a6f87a935aa2c282ce0e2a3https://doi.org/10.1128/jvi.66.9.5667-5670.1992
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