Key result
Fresh frozen plasma benefits specific coagulopathies but lacks justification for volume expansion or nutritional support.
Fresh frozen plasma should only be used to treat bleeding episodes or prepare patients for surgery in certain defined situations. Definite indications for the use of FFP: 1. Replacement of single coagulation factor deficiencies, where a specific or combined factor concentrate is unavailable. 2. Immediate reversal or warfarin effect. 3. Acute disseminated intravascular coagulation (DIC). 4. Thrombotic thrombocytopenic purpura (TTP). Conditional uses: FFP only indicated in the presence of bleeding and disturbed coagulation: 1. Massive transfusion. 2. Liver disease. 3. cardiopulmonary bypass surgery. 4. Special paediatric indications. No justification for the use of FFP: 1. Hypovolaemia. 2. Plasma exchange procedures. 3. 'Formula' replacement. 4. Nutritional support. 5. Treatment of immunodeficiency states.
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A et al. (1992) conducted a review in Bleeding episodes or preparation for surgery. Fresh frozen plasma was evaluated. Fresh frozen plasma is indicated for specific bleeding conditions (e.g., coagulation factor deficiencies, warfarin reversal, DIC, TTP) but lacks justification for hypovolemia or nutritional support.
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