A method of seropheresis is described by which serum is obtained from blood donors instead of plasma or whole blood. The donor is bled into a dry plastic bag and the serum is separated from the red cells by centrifugation before the blood has time to clot. The red cells are then mixed with anticoagulant and returned to the blood donor immediately. Seropheresis can be performed as a single venipuncture procedure and permits the production of large amounts of serum from an individual blood donor.
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Allan Kliman (1963) studied this question.
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