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May 1, 1994Technometrics

Cross-Over Trials in Clinical Research

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Authors

SSSJ Senn

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Overview

Methodological text details statistical models and design strategies for cross-over clinical trials, highlighting approaches to address carry-over effects and optimize treatment comparisons.

Key Points

  • To provide a comprehensive statistical and practical guide to the design, execution, and analysis of cross-over trials in clinical research.
  • Covers fundamental principles of clinical estimation and standard two-period, two-treatment (AB/BA) designs using normal and non-normal outcome data.
  • Extends analytical frameworks to multi-period designs involving three or more treatments alongside specialized experimental structures.
  • Outlines graphical presentations, trial execution issues, and formal mathematical models for handling carry-over effects.
  • Presents tailored statistical techniques for analyzing continuous, binary, and categorical end points in repeated-treatment settings.
  • Demonstrates specialized approaches to identify, prevent, and mathematically model lingering treatment carry-over across intervention periods.
  • Establishes systematic standards for graphical display and tabular reporting to ensure transparent interpretation of cross-over data.

Cite This Study

SJ Senn (1994) studied this question.

synapsesocial.com/papers/6a6f8a6ca528af2d65c30a29https://doi.org/10.1080/00401706.1994.10485798
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Paired and AB/BA Cross-Over Design in Early Phase Clinical Trials: A Closer Look at Within-Subject Variance Bias.2026
  2. 2Paired and AB / BA Cross‐Over Design in Early Phase Clinical Trials: A Closer Look at Within‐Subject Variance Bias2026
  3. 3An Introduction to the Crossover Trial Design2024 · 11 citations
  4. 4Clinical Trials: A Practical Approach.1984 · 2,951 citations
  5. 5Behavioral carry-over effect and power consideration in crossover trials2024 · 16 citations