Population
Human blood platelets and purified thrombospondin
Comparison
Purification and digestion in the presence of… vs Purification and digestion in the presence of EDTA
Design
Preclinical
Authors
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Maintain calcium during thrombospondin isolation to preserve native conformation; extends structural data but leaves open functional relevance in platelets.
The presence of calcium preserves the native, less asymmetric structure of platelet thrombospondin, which is disrupted by EDTA during isolation.
Lawler et al. (1982) studied this question.
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