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Vascular endothelial growth factor is a major regulator of angiogenesis, and its discovery has led to FDA-approved VEGF inhibitors for advanced cancer and age-related macular degeneration.
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Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
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Napoleone Ferrara (2009) conducted a review in Angiogenesis. Vascular Endothelial Growth Factor (VEGF) was evaluated. Vascular endothelial growth factor is a major regulator of angiogenesis, and its discovery has led to FDA-approved VEGF inhibitors for advanced cancer and age-related macular degeneration.
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