Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 24, 2008New England Journal of Medicine

Calcific Aortic Stenosis — Time to Look More Closely at the Valve

View Full Paper
Ask AI
Bookmark
Share

Design

Review

Authors

Catherine M OttoCatherine M OttoCardiac Imaging

Discussion

Loading...

Member takes

Implication

May prompt exploration of targeted molecular therapies; leaves open whether such interventions will improve clinical outcomes.

Key Points

  • To review the active cellular, genetic, and mechanical mechanisms that drive the progression of calcific aortic stenosis beyond simple age-related wear.
  • Synthesized molecular, genetic, and clinical evidence evaluating initiating triggers and cellular pathways involved in aortic valve calcification.
  • Mechanical stress serves as the primary initiating factor driving pathological valve remodeling.
  • Aortic valve calcification operates as an active, regulated biological process mediated by specific cellular and genetic pathways rather than passive degeneration.

Cite This Study

Catherine M Otto (2008) studied this question.

synapsesocial.com/papers/6a6f8cdce36a167817e142a8https://doi.org/10.1056/nejme0807001
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice2006 · 227 citations
  2. 2Presence of Oxidized Low Density Lipoprotein in Nonrheumatic Stenotic Aortic Valves1999 · 416 citations
  3. 3Apolipoproteins B, (a), and E Accumulate in the Morphologically Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis1996 · 558 citations
  4. 4Atorvastatin Inhibits Hypercholesterolemia-Induced Calcification in the Aortic Valves via the Lrp5 Receptor Pathway2005 · 264 citations
  5. 5Frequency by Decades of Unicuspid, Bicuspid, and Tricuspid Aortic Valves in Adults Having Isolated Aortic Valve Replacement for Aortic Stenosis, With or Without Associated Aortic Regurgitation2005 · 1,009 citations