Why the study?
Does banding of pulmonary veins induce progressive pulmonary venous obstruction and associated hemodynamic and structural changes in a piglet model?
Population
50 piglets (animal model of progressive central pulmonary venous obstruction)
Comparison
Banding of pulmonary veins (n=20) vs Sham operation and nonoperated controls
Design
Preclinical
Follow-up
6 weeks
Authors
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Piglet pulmonary vein banding reproduces obstruction-like hemodynamics and fibrosis; hypothesis-generating for intervention timing before clinical translation.
Does banding of pulmonary veins induce progressive pulmonary venous obstruction and associated hemodynamic and structural changes in a piglet model?
In a piglet model of pulmonary venous obstruction, early remodeling increases distensibility, but subsequent extensive fibrosis may explain the failure of late interventions.
LaBourene et al. (1990) studied this question.
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