Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis
Population
127 patients at the time of diagnosis
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Suggests phenotype-specific assessment at diagnosis for cardiac amyloidosis; hypothesis-generating for TTR versus AL monitoring and progression.
Structured PICO
P
Population
127 patients (79 with light-chain [AL] amyloidosis and 48 with transthyretin [TTR] amyloidosis) at the time of diagnosis
O
Outcome
Clinical and echocardiographic profiles at the time of diagnosissurrogate
At diagnosis, TTR amyloidosis presents with more advanced structural cardiac involvement but less severe heart failure symptoms and biomarker elevation compared to AL amyloidosis.
Cite This Study
Cappelli et al. (2015) studied this question.