Lactobacillus Combined with Inulin Ameliorated Memory Deficit by Modulating Gut Microbiota and Metabolic Profiles

This is the authors' abstract. We don't add key points for this paper.

This study aimed to investigate the effects of a combination of Lactobacillus and inulin (LI) on memory impairment, gut microbiota composition, and metabolic profiles in APP/PS1 transgenic mice (MC). Mice treated with LI exhibited significant improvements in memory performance, along with marked reductions in Aβ plaque deposition, neuroinflammation, and oxidative stress levels. Treatment with LI significantly increased the relative abundances of unclassified_f__Lachnospiraceae, Faecalibaculum, and Blautia, while significantly reducing Candidatus_Saccharimonas. Metabolomics analysis revealed that LI treatment led to elevated levels of acetylcholine, LysoPC (17:0), and sphinganine 1-phosphate, and a significant decrease in phosphocholine level. KEGG pathway analysis indicated that glycerophospholipid and sphingolipid metabolism were likely involved. In particular, Faecalibaculum and Candidatus_Saccharimonas may improve memory by modulating glycerophospholipid and sphingolipid pathways, respectively. These findings offer novel insights into microbiota-targeted strategies for memory enhancement.