Population
Ovariectomized rat carotid arteries
Comparison
Perivascular injury by silicone collar around… vs Contralateral uninjured arteries
Design
Preclinical
Follow-up
14 days
Authors
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Hypothesis-generating in estrogen-deficient models; leaves open translation to human carotid disease or therapy.
In ovariectomized rats, perivascular injury of the carotid artery impairs Ang II-induced contraction via increased NO production and decreased calcium influx.
Fukada et al. (2004) studied this question.
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