June 1, 1996Journal of Cardiovascular Pharmacology
Role of Nitric Oxide in the Attenuated Pressor Responses of Pregnant or Sodium-Deplete Sheep
Population
Pregnant and postpartum sheep, and sodium-replete and sodium-deplete sheep
Comparison
Angiotensin II and norepinephrine with… vs Postpartum sheep, sodium-replete sheep, and…
Design
Preclinical
Authors
Discussion
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Implication
NO modulates blunted Ang II responses in pregnant sheep; extends mechanistic data but leaves open human translation.
Structured PICO
P
Population
Pregnant and postpartum sheep, and sodium-replete and sodium-deplete sheep (by 24 h of parotid salivary drainage)
I
Intervention
Angiotensin II (5, 10, 25, 50 micrograms/h) and norepinephrine (0.32, 0.65, 1.62, 3.24 mg/h) with pretreatment with N omega-nitro-L-arginine (NOLA 10 mg/kg)
C
Comparator
Postpartum sheep, sodium-replete sheep, and responses without NOLA pretreatment
O
Outcome
Pressor responses (blood pressure changes)surrogate
Nitric oxide plays a role in modulating the attenuated pressor responses to Angiotensin II in pregnant and sodium-deplete sheep.
Cite This Study
Tresham et al. (1996) studied this question.