Why the study?
Is plasma atrial natriuretic peptide (ANP) elevated in patients with severe hypertension compared to healthy controls?
Is plasma atrial natriuretic peptide (ANP) elevated in patients with severe hypertension compared to healthy controls?
Plasma ANP levels do not correlate with blood pressure in severe hypertension, suggesting elevated ANP is not directly caused by high blood pressure itself.
ANP testing adds no value in severe hypertension; leaves open its role in other phenotypes or compensatory pathways.
Atrial natriuretic peptide-like immunoreactivity in plasma (ANP-LI) was studied in patients with severe hypertension (n = 21) and in matched healthy control subjects. There was no correlation between ANP-LI and blood pressure, and the distribution of ANP-LI values did not differ between the two groups. These results are consistent with the assumption that an increase in ANP is not caused by elevated blood pressure, although elevated ANP-LI may be found in subgroups of hypertensive subjects with increased atrial pressures due to, for example, cardiac failure.
No takes yet. Share an insight, caveat, or question.
Ekholm et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: