September 30, 2003Proceedings of the National Academy of SciencesOpen Access

Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling

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Population

Washed platelets from wild-type, CD40-/-, and diYF mouse strains

Comparison

Soluble CD40 ligand (sCD40L) vs Mutant D117E-sCD40L, Integrilin, or anti-CD40…

Design

Preclinical

Authors

KPK. S. Srinivasa PrasadUniversity of Illinois Chicago PAPatrick AndréC4 Therapeutics (United States)MHMing-Shan HeTzu Chi University

Discussion

Member takes

Implication

Should not yet change practice; leaves open sCD40L as an antithrombotic target pending human validation.

Structured PICO

Population

Washed platelets from wild-type, CD40-/-, and diYF mouse strains

Intervention

Soluble CD40 ligand (sCD40L)

Comparator

Mutant D117E-sCD40L, Integrilin (alphaIIbbeta3 antagonist), or anti-CD40 antibody

Outcome

Platelet activation (measured by fibrinogen binding, microparticle formation, thrombus formation under arterial shear rate, and beta3 tyrosine phosphorylation)surrogate

This study identifies sCD40L as a primary platelet agonist that activates platelets through alphaIIbbeta3 outside-in signaling, providing a mechanistic link to thrombosis.

Cite This Study

Prasad et al. (2003) studied this question.

synapsesocial.com/papers/6a6f93006c240de38cdb8595 https://doi.org/10.1073/pnas.2032886100

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Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider