Key result
ABCA1 deficiency lowers apoB and apoA-I with conflicting effects on atherosclerosis.
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Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on atherosclerosis.
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Aiello et al. (2003) conducted a review in Tangier disease and atherosclerosis. ABCA1 deficiency was evaluated. ABCA1-deficient mice exhibit a phenotype paralleling human Tangier disease, featuring substantial reductions in apolipoprotein B and AI with confounding effects on atherosclerosis.
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