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October 16, 2010The Journal of ImmunologyOpen Access

A Critical Function of Th17 Proinflammatory Cells in the Development of Atherosclerotic Plaque in Mice

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Authors

QGQi GaoShanxi University YJYang JiangFirst Affiliated Hospital of Xinxiang Medical University TMTian MaBeijing University of Civil Engineering and Architecture

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Implication

Preclinical study demonstrates that Th17 cells and interleukin-17 drive atherosclerotic plaque formation in mice, suggesting targeting interleukin-17 could treat atherosclerosis.

Key Points

To evaluate the production and functional contribution of Th17 and Th1 cells to the progression of atherosclerotic plaque.
Assessed proportions of Th17 and Th1 cells and quantified expression of IL-17 and RORγt in atherosclerosis-prone ApoE(-/-) mice compared with wild-type littermates.
Treated ApoE(-/-) mice with either neutralizing anti-IL-17 antibody or recombinant IL-17 to evaluate the functional impact of IL-17 signaling on plaque development.
ApoE(-/-) mice showed increased proportions of Th17 and Th1 cells compared to wild-type controls, with elevated IL-17 and RORγt expression localized to arterial walls containing plaque.
Th17 cell frequencies correlated positively with the magnitude of atherosclerotic plaque in ApoE(-/-) mice.
Treatment with neutralizing anti-IL-17 antibody dramatically inhibited plaque development, whereas recombinant IL-17 administration significantly promoted plaque formation.

Cite This Study

Gao et al. (2010) studied this question.

synapsesocial.com/papers/6a6f94fd75498292b708f70d https://doi.org/10.4049/jimmunol.1000116

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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