Key result
Atherosclerotic plaque smooth muscle cells show distinct phenotypic changes compared to medial cells.
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The smooth muscle cells within the human atherosclerotic plaque differ from the cells of the media. These phenotype changes, the mechanisms responsible, and their possible relevance to the formation of the plaque are discussed.
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Campbell et al. (1994) studied this question. Smooth muscle cells within human atherosclerotic plaques exhibit distinct phenotypic changes compared to cells of the media, which may be relevant to plaque formation.
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