What question did this study set out to answer?

To review recent findings on how lipids and related factors initiate endothelial-to-mesenchymal transition (EndMT) and influence atherosclerotic plaque stability and sex-specific disease dynamics.

August 15, 2026Current Opinion in Lipidology

Lipids in endothelial-to-mesenchymal transition

View Full Paper

Ask AI

Bookmark

Authors

CTChristina TripsasUniversity of California, Los Angeles ATAbigail Y. TsaiDepartment of Physiological Sciences JHJeffrey J. HsuHeart Failure & Transplant

Discussion

Member takes

Implication

Narrative review uncovers the role of lipids in driving endothelial-to-mesenchymal transition during atherosclerosis, highlighting new targets for plaque stability.

Key Points

To review recent findings on how lipids and related factors initiate endothelial-to-mesenchymal transition (EndMT) and influence atherosclerotic plaque stability and sex-specific disease dynamics.
Synthesized recent literature investigating molecular mechanisms linking lipid regulation to EndMT induction in cardiovascular pathology.
Evaluated preclinical therapeutic approaches targeting lipid modulation and EndMT-specific pathways to control vascular lipid deposition.
Lipids and associated regulatory factors trigger distinct EndMT signaling cascades that accelerate vascular remodeling in atherosclerosis.
EndMT progression directly impacts atherosclerotic plaque composition and structural stability, showing distinct sex-specific mechanistic differences.
Modulating systemic lipid levels or intervening in EndMT-specific pathways reduces pathological vascular lipid deposition.

Cite This Study

Tripsas et al. (2026) studied this question.

synapsesocial.com/papers/6a8019a975c2e31742c85aaa https://doi.org/10.1097/mol.0000000000001051

View Full Paper

Ask AI

Bookmark

Implication

Narrative review uncovers the role of lipids in driving endothelial-to-mesenchymal transition during atherosclerosis, highlighting new targets for plaque stability.

Lipids in endothelial-to-mesenchymal transition

Discussion

Member takes

Implication

Key Points

Cite This Study

Lipids in endothelial-to-mesenchymal transition

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider