Why the study?
Does simvastatin alter adipocyte physiology and whole-body insulin sensitivity in ob/ob mice?
Population
ob/ob mice and adipocytes
Design
Preclinical
Authors
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Does not affect insulin sensitivity despite adipocyte changes in ob/ob mice; leaves open translation to humans and clinical relevance.
Does simvastatin alter adipocyte physiology and whole-body insulin sensitivity in ob/ob mice?
Simvastatin exerts pleiotropic effects on adipocyte physiology, including altered adiponectin secretion and reduced adiposity, without affecting whole-body insulin sensitivity in ob/ob mice.
Khan et al. (2009) studied this question.
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