Why the study?
Does severe hypoalbuminemia affect the predictive value of the APACHE II score for mortality in severely ill patients?
Population
93 severely ill patients, including 28 with severe hypoalbuminemia and 65 with mildly low or normal albumin.
Comparison
Severe hypoalbuminemia (serum albumin < 2.5 g/dL) vs Mildly low or normal albumin concentrations
Design
Cohort
Authors
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APACHE II underpredicts mortality in severe hypoalbuminemia; hypothesis-generating for albumin-adjusted risk models in ICU cohorts.
Does severe hypoalbuminemia affect the predictive value of the APACHE II score for mortality in severely ill patients?
Severe hypoalbuminemia significantly increases mortality risk beyond what is predicted by the APACHE II score, indicating the score is less accurate in this specific patient population.
Pollak et al. (1991) studied this question.
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