What question did this study set out to answer?

To determine whether traumatic injury induces systemic inflammation and morphologic tissue alterations in organs not directly injured.

December 1, 1988Archives of Surgery

Whole-Body Inflammation in Trauma Patients

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Authors

HNHans K. S. NuytinckAmphia Ziekenhuis

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Implication

Autopsy review reveals widespread inflammation and increased organ weights in fatal trauma patients, suggesting early preclinical systemic organ failure.

Key Points

To determine whether traumatic injury induces systemic inflammation and morphologic tissue alterations in organs not directly injured.
Reviewed autopsy specimens and postmortem pathology reports in 35 fatal trauma cases.
Widespread inflammation, tissue damage, and elevated organ weights appeared in primarily uninjured organs across all cases, independent of time of death and present even in isolated brain injury.
Inflammatory changes and organ weight gains peaked in patients who died of adult respiratory distress syndrome, hypovolemic shock, or multiple organ failure.
Pathology closely mirrored animal patterns induced by complement activation paired with hypoxia, reflecting early preclinical stages of multiple organ failure.

Cite This Study

Hans K. S. Nuytinck (1988) studied this question.

synapsesocial.com/papers/6a6f970a439bab0cabc2d9b8 https://doi.org/10.1001/archsurg.1988.01400360089016

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Implication

Autopsy review reveals widespread inflammation and increased organ weights in fatal trauma patients, suggesting early preclinical systemic organ failure.

Whole-Body Inflammation in Trauma Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Whole-Body Inflammation in Trauma Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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