Observational study reveals seizure frequency correlates with estrogen-to-progesterone ratios in women with partial epilepsy, indicating hormonal fluctuations influence seizure susceptibility.
Nine periods in seven women with partial epilepsy have been invetigated with respect to frequency of fits, and estrogen-progesterone levels in blood plasma. Six cycles with ovulation showed a positive correlation between the number of secondary generalized seizures and the mean estrogen/progesterone (E/P) ratios and a negative correlation to plasma progesterone levels. Three periods without ovulation showed an increase in the number of fits during days of high estrogen. The number of fits seemed not to be correlated to changes in body weight.
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Torbjörn Bäckström (1976) studied this question.
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