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Osteosarcoma (OS) is a primary highly malignant tumor of bone, affecting predominately adolescents and young adults between 10 and 20 years of age. OS is characterized by an extremely aggressive clinical course, with a rapid development of metastasis to the lung and distant bones. J. Cell. Physiol. 9999: 2718–2727, 2015.
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Laschi et al. (2015) studied this question.
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