Population
Patients with chronic lung disease complicated by secondary pulmonary hypertension
Design
Review
Authors
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May support angiogenesis as protective against pulmonary vascular resistance in chronic lung disease; leaves open therapeutic targeting pending validation.
This review challenges the traditional view that angiogenesis does not occur in the adult pulmonary circulation, suggesting it may play a role in attenuating increased vascular resistance in chronic lung disease.
Hopkins et al. (2002) studied this question.
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