Why the study?
Does metabolic syndrome X reduce muscle perfusion and induce vascular remodeling in the obese Zucker rat model?
Population
Obese Zucker rats (animal model of metabolic syndrome X)
Comparison
Metabolic syndrome X (obese phenotype) vs Lean Zucker rats
Design
Preclinical
Authors
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Hypothesis-generating for perfusion deficits in metabolic syndrome; does not support clinical practice changes.
Does metabolic syndrome X reduce muscle perfusion and induce vascular remodeling in the obese Zucker rat model?
Metabolic syndrome X reduces hindlimb blood flow and induces microvascular remodeling favoring smaller, less distensible vessels, which may limit maximum perfusion capacity.
Stepp et al. (2004) studied this question.
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