Why the study?
Melissa officinalis and Lavandula angustifolia have been traditionally used for depression, but adequate clinical trials were lacking to support their efficacy compared to standard treatments.
Does Melissa officinalis or Lavandula angustifolia improve depression symptoms compared to fluoxetine in adult outpatients with mild to moderate depression?
Comparison
M. officinalis (2 g daily) vs L. angustifolia (2 g daily) vs fluoxetine (20 mg daily)
Design
Randomized, double-blind clinical trial
Follow-up
8 weeks
Authors
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Herbs match fluoxetine efficacy in mild-moderate depression; extends traditional claims with RCT evidence.
Does Melissa officinalis or Lavandula angustifolia improve depression symptoms compared to fluoxetine in adult outpatients with mild to moderate depression?
Melissa officinalis and Lavandula angustifolia demonstrated similar efficacy to fluoxetine in reducing symptoms of mild to moderate depression over 8 weeks, with potentially fewer side effects.
Araj‐Khodaei et al. (2020) studied this question.
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