What question did this study set out to answer?

To identify clinical and environmental risk factors for blackfoot disease and evaluate associated cardiovascular and cancer mortality linked to high-arsenic artesian well water exposure.

September 1, 1988Arteriosclerosis An Official Journal of the American Heart Association Inc

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease.

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Authors

CCC-J ChenChina Three Gorges University MWMeei‐Maan WuNational Health Research Institutes SLShoei‐Sheng LeeNational Taiwan University

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Implication

Case-control and cohort analysis reveals elevated vascular and cancer mortality in arsenic-exposed blackfoot disease patients, highlighting the atherogenic and carcinogenic risks of contaminated...

Key Points

To identify clinical and environmental risk factors for blackfoot disease and evaluate associated cardiovascular and cancer mortality linked to high-arsenic artesian well water exposure.
Conducted a case-control study with 241 blackfoot disease cases (169 with amputations) and 759 age-, sex-, and residence-matched community controls using multiple logistic regression.
Tracked cancer and cardiovascular mortality across a cohort of 789 blackfoot disease patients followed for 15 years using life-table analysis compared against local and general populations in Taiwan.
Multiple logistic regression demonstrated that artesian well water consumption, arsenic poisoning, familial history of blackfoot disease, and undernourishment were significantly associated with developing blackfoot disease.
Over 15 years of follow-up, blackfoot disease patients exhibited significantly higher mortality rates from cardiovascular diseases, peripheral vascular diseases, and cancers of the bladder, skin, lung, and liver relative to regional and national populations.

Cite This Study

Chen et al. (1988) studied this question.

synapsesocial.com/papers/6a6f9ee26ceb2bbd16dfb28d https://doi.org/10.1161/01.atv.8.5.452

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Implication

Case-control and cohort analysis reveals elevated vascular and cancer mortality in arsenic-exposed blackfoot disease patients, highlighting the atherogenic and carcinogenic risks of contaminated...

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease.

Discussion

Member takes

Implication

Key Points

Cite This Study

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease.

Discussion

Member takes

Implication

Key Points

Cite This Study

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