An outbreak of secondary methemoglobinemia was directly traceable to an aromatic amino compound present in the soap used for the preparation of enema solutions. This compound, while not itself a producer of methemoglobin, did, under the conditions of use, become converted into a substance which produced methemoglobin. Users of materials containing aromatic amino compounds should be aware of the possibility of such occurrences.
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Johnson et al. (1963) studied this question.