Long Term Dicumarol Therapy

Case Reports1 April 1950LONG TERM DICUMAROL THERAPYRAYMOND L. RICE, M.D., M. SC. (Med.), F.A.C.P., JACK S. ACKERMAN, M.D., ROBERT SAICHEK, M.D.RAYMOND L. RICE, M.D., M. SC. (Med.), F.A.C.P., JACK S. ACKERMAN, M.D., ROBERT SAICHEK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-4-735 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGround work in the use of Dicumarol for preventing the extension of coronary thrombosis and the development of mural thrombi in the presence of myocardial infarction was laid by Solandt, Nassim, and Best1 in 1938. Using the anticoagulant, heparin, they were able to prevent the formation of coronary thrombi and intracardiac mural thrombi when deliberate experiments were performed to produce these lesions in experimental animals.With the advent of Dicumarol numerous workers2, 3, 4 began its use in the treatment of coronary thrombosis with myocardial infarction and its complications.Recently the Committee for the Evaluation of Anticoagulants in the Treatment...Bibliography1. SolandtBest DYDH: Heparin and coronary thrombosis in experimental animals, Lancet 2: 130-152, 1939. Solandt, D. Y., Nassim, R., and Best, C. H.: Production and prevention of cardiac mural thrombosis in dogs, Lancet 2: 592-595, 1939. Google Scholar2. Wright IS: Experiences with Dicumarol in the treatment of coronary thrombosis, Proc. Am. Federation Clin. Research 2: 101-102, 1945. Experiences with myocardial infarction, Am. Heart J. 32: 20-31, 1946. MedlineGoogle Scholar3. NicholPage ESSW: Dicumarol therapy in acute coronary thrombosis: results in 50 attacks, J. Florida M. A. 32: 365-370, 1946. MedlineGoogle Scholar4. PetersGuytherBrambel HRJREC: Dicumarol in acute coronary thrombosis, J. A. M. A. 130: 398-403, 1946. CrossrefMedlineGoogle Scholar5. WrightMarpleBeck ISCDDF: Anticoagulant therapy of coronary thrombosis with myocardial infarction, J. A. M. A. 138: 1074-1079, 1948. CrossrefMedlineGoogle Scholar6. Wright IS: The use of anticoagulants in the treatment of diseases of the heart and blood vessels, Ann. Int. Med. 30: 80-91, 1949. LinkGoogle Scholar7. ZiffrenOwenHoffmanSmith SECAGRHP: A simple bedside test for control of vitamin K therapy, Tech. Bull. Reg. Med. Tech. 1: 13-16, 1940. Google Scholar8. ZiffrenOwenHoffmanSmith SECAGRHP: Control of vitamin K therapy compensatory mechanisms at low prothrombin levels, Proc. Soc. Exper. Biol. and Med. 40: 595-597, 1939. CrossrefGoogle Scholar9. NicholFassett ESDW: An attempt to forestall acute coronary thrombosis: preliminary note on the continuous use of Dicumarol, South M. J. 40: 63l-637, 1947. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wisconsin*Received for publication June 11, 1949.From the Department of Medicine, Mount Sinai Hospital, and the Marquette University School of Medicine, Milwaukee, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn Evaluation of the Effect of Continuous Long-Term Anticoagulant Therapy on the Prognosis of Myocardial InfarctionLong Term Dicumarol Therapy in Thromboembolic Conditions, Especially Coronary Thrombosis.1 1 April 1950Volume 32, Issue 4Page: 735-745KeywordsAnticoagulantsHeparinHospital medicineLesionsMyocardial infarctionThrombosis ePublished: 1 December 2008 Issue Published: 1 April 1950 PDF downloadLoading ...