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August 15, 2018Platelets

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

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Authors

ASAlexandre SlaterUniversity of NottinghamGPGina PerrellaUniversity College BirminghamMOMarie-Blanche OnselaerUniversity of Birmingham

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Implication

Clarifies reasons for discrepant GPVI-fibrin binding reports; leaves open the dominant receptor form in thrombus stabilization.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Slater et al. (2018) studied this question.

synapsesocial.com/papers/6a6fa14f31a3df824327f864https://doi.org/10.1080/09537104.2018.1508649
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Also Consider

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  1. 1Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity2011 · 102 citations
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  5. 5Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood2012 · 100 citations