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December 9, 2011Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Platelet activation induces a shift toward GPVI dimerization, which correlates with P-selectin exposure in patients with coronary artery disease and is limited by P2Y12 antagonists.

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Population

Human resting platelets and platelets from patients experiencing coronary artery disease

Comparison

Activation by soluble agonists or von Willebrand… vs Resting state

Design

Preclinical

Key result

Platelet activation induces a shift toward GPVI dimerization, which correlates with P-selectin exposure in patients with coronary artery disease and is limited by P2Y12 antagonists.

Authors

SLStéphane LoyauBDBénédicte DumontVOVéronique Ollivier

Discussion

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Overview

GPVI dimerization assessment should not yet alter CAD practice; leaves open its value as reactivity marker or therapeutic target beyond P2Y12 inhibition.

Structured PICO

P
Population
Human resting platelets and platelets from patients experiencing coronary artery disease
E
Exposure
Activation by soluble agonists or von Willebrand factor; P2Y12 antagonists
C
Comparator
Resting state
O
Outcome
GPVI dimerization and platelet adhesion to collagensurrogate

GPVI dimerization is an active process that induces receptor competence and may serve as a new marker to analyze platelet reactivity in coronary artery disease.

Cite This Study

Loyau et al. (2011) studied Coronary artery disease. Platelet activation was evaluated on GPVI dimerization and platelet adhesion to collagen. Platelet activation induces a shift toward GPVI dimerization, which correlates with P-selectin exposure in patients with coronary artery disease and is limited by P2Y12 antagonists.

synapsesocial.com/papers/6a331e093f4eb47fd20cff04https://doi.org/10.1161/atvbaha.111.241067
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?2021 · 21 citations
  2. 2Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation2017 · 109 citations
  3. 3Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo2003 · 197 citations
  4. 4Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation2015 · 271 citations
  5. 5Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency1995 · 159 citations