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March 28, 2023Journal of Thrombosis and HaemostasisOpen Access

Glycoprotein VI interacts with fibrin to promote thrombus growth and presents a viable antithrombotic target.

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Why the study?

GPVI is a viable antithrombotic target participating in arterial thrombosis while being less involved in hemostasis, prompting review of its interactions with fibrin and fibrinogen and emerging therapeutic developments.

Design

Review

Key result

Glycoprotein VI interacts with fibrin and fibrinogen to promote thrombus growth and stability, presenting a viable antithrombotic target with therapies currently in clinical trials.

Authors

PMPierre ManginEGElizabeth E. GardinerRARobert A.S. Ariëns

Discussion

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Overview

Supports ongoing GPVI inhibitor trials in arterial thrombosis; leaves open net clinical benefit versus bleeding risk.

PICO

P
Population
Thrombosis
I
Intervention / Comparator
GPVI targeted therapies

Targeting the GPVI-fibrin(ogen) interaction offers a promising therapeutic strategy to prevent arterial thrombosis while preserving normal hemostasis.

Limitations

  • Therapies are currently being tested for acute clinical situations and have not yet been evaluated for long-term chronic indications.
  • Molecular mechanisms by which GPVI mediates inflammatory responses are largely unknown.

Cite This Study

Mangin et al. (2023) conducted a review in Thrombosis. GPVI targeted therapies was evaluated. Glycoprotein VI interacts with fibrin and fibrinogen to promote thrombus growth and stability, presenting a viable antithrombotic target with therapies currently in clinical trials.

synapsesocial.com/papers/6aa3ce97fd19ae9969b15087https://doi.org/10.1016/j.jtha.2023.03.022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation2015 · 271 citations
  2. 2Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment2025 · 6 citations
  3. 3Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI2010 · 15 citations
  4. 4Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke2016 · 32 citations
  5. 5From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks2019 · 28 citations