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March 1, 2018Thrombosis and HaemostasisOpen Access

Dimeric glycoprotein VI binds to collagen but not to fibrin in experimental systems closely related to atherothrombosis, challenging previous reports of fibrin as a novel GPVI ligand.

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Design

Editorial

Key result

Dimeric glycoprotein VI binds to collagen but not to fibrin in experimental systems closely related to atherothrombosis, challenging previous reports of fibrin as a novel GPVI ligand.

Authors

MGMeinrad Gawaz

Discussion

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Member takes

Overview

Questions fibrin-GPVI interaction for antithrombotic development; leaves open optimal GPVI targets in atherothrombosis.

PICO

P
Population
Atherothrombosis
I
Intervention / Comparator
Dimeric glycoprotein VI (GPVI)

This editorial discusses conflicting preclinical evidence on whether fibrin is a direct ligand for platelet glycoprotein VI (GPVI), which has implications for developing novel GPVI-targeted antithrombotic therapies.

Limitations

  • Previous studies concluding fibrin is a direct ligand of GPVI were primarily based on indirect measures of GPVI function.
  • Significant methodological differences exist between published studies and the discussed work that might explain conflicting results.

Cite This Study

Meinrad Gawaz (2018) conducted an editorial in Atherothrombosis. Dimeric glycoprotein VI (GPVI) was evaluated. Dimeric glycoprotein VI binds to collagen but not to fibrin in experimental systems closely related to atherothrombosis, challenging previous reports of fibrin as a novel GPVI ligand.

synapsesocial.com/papers/6a8440ffcdf3a848bdbd895chttps://doi.org/10.1055/s-0038-1635080
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo2003 · 197 citations
  2. 2Glycoprotein VI interplay with fibrin(ogen) in thrombosis2023 · 32 citations
  3. 3Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation2017 · 109 citations
  4. 4Blocking platelet glycoprotein VI (GPVI) as a promising antithrombotic treatment2025 · 6 citations
  5. 5GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease2024 · 24 citations