Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo
Why the study?
Does soluble GPVI-Fc prevent platelet adhesion and aggregation in models of vascular injury?
Population
In vitro models and in vivo mouse model of arterial thrombosis
Comparison
Soluble dimeric form of glycoprotein VI (GPVI-Fc) vs Control Fc lacking the external GPVI domain
Design
Preclinical
Authors
Discussion
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Member takes
Implication
GPVI-Fc may inhibit thrombosis in preclinical models; leaves open translation to human antithrombotic therapy.
Structured PICO
Does soluble GPVI-Fc prevent platelet adhesion and aggregation in models of vascular injury?
P
Population
In vitro models (CHO cells expressing human GPVI, platelets) and in vivo mouse model of arterial thrombosis (mouse carotid artery injury)
I
Intervention
Soluble dimeric form of glycoprotein VI (GPVI-Fc)
C
Comparator
Control Fc lacking the external GPVI domain
O
Outcome
Platelet adhesion, aggregation, and thrombus formationsurrogate
Soluble GPVI-Fc effectively inhibits platelet adhesion and thrombus formation at sites of vascular injury in preclinical models, suggesting potential as a novel antithrombotic therapy.
Cite This Study
Maßberg et al. (2003) studied this question.