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January 1, 1995British Journal of Haematology

Shape change, aggregation and ATP release were completely absent in response to 1-5 micrograms/ml collagen, while adhesion to coated collagen was mildly affected (40-60% of normal).

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Population

A female patient with a mild bleeding history whose platelets expressed 10% GPVI of normal platelets (n=1)

Comparison

In vitro platelet function testing vs Normal platelets

Design

Case_report

Authors

MAMorio AraiNYNaomasa YamamotoMMMasaaki Moroi

Discussion

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Overview

Case suggests GPVI differentially mediates collagen responses; hypothesis-generating for platelet disorder evaluation and requires validation.

Structured PICO

P
Population
A female patient with a mild bleeding history whose platelets expressed 10% GPVI of normal platelets (n=1)
I
Intervention
In vitro platelet function testing (response to collagen, ADP, Ca2+ ionophore A23187)
C
Comparator
Normal platelets
O
Outcome
Platelet shape change, aggregation, ATP release, and adhesion in response to collagensurrogate

Platelet GPVI appears less involved in adhesion to collagen than in shape change and aggregation induced by collagen.

Cite This Study

Arai et al. (1995) studied this question.

synapsesocial.com/papers/6a918bc0692913561f11fc91https://doi.org/10.1111/j.1365-2141.1995.tb08900.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI2010 · 15 citations
  2. 2Soluble glycoprotein VI dimer inhibits platelet adhesion and aggregation to the injured vessel wall in vivo2003 · 197 citations
  3. 3Distinct roles of GPVI and integrin α<sub>2</sub>β<sub>1</sub> in platelet shape change and aggregation induced by different collagens2002 · 86 citations
  4. 4Platelet Glycoprotein VI Dimerization, an Active Process Inducing Receptor Competence, Is an Indicator of Platelet Reactivity2011 · 101 citations
  5. 5Platelets deficient in glycoprotein IIIb aggregate normally to collagens type I and III but not to collagen type V1993 · 60 citations