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September 1, 2002British Journal of PharmacologyOpen Access

Distinct roles of GPVI and integrin α2β1 in platelet shape change and aggregation induced by different collagens

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Population

Platelets (including FcRgamma chain-deficient, CD36-deficient, and human platelets)

Design

Preclinical

Authors

GJGavin E. JarvisBABen AtkinsonDSDaniel Snell

Discussion

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Overview

GPVI/FcRγ remains a viable antithrombotic target; confirms complex dependence across collagens but should not yet change practice.

Structured PICO

P
Population
Platelets (including FcRgamma chain-deficient, CD36-deficient, and human platelets)
I
Intervention
Bovine collagen types I-V, native equine tendon collagen fibrils, and collagen-related peptide (CRP)
O
Outcome
Platelet aggregation and shape changesurrogate

This preclinical study confirms the critical role of the GPVI/FcRgamma chain complex in platelet activation by various collagens, with alpha2beta1 integrin playing a modulatory role.

Cite This Study

Jarvis et al. (2002) studied this question.

synapsesocial.com/papers/6a7082e1e5469ee92be13bb6https://doi.org/10.1038/sj.bjp.0704834
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelets Interact with Soluble and Insoluble Collagens through Characteristically Different Reactions1998 · 132 citations
  2. 2Normal aggregations of glycoprotein IV (CD36)‐deficient platelets from seven healthy Japanese donors1992 · 56 citations
  3. 3Preaggregation reactions of platelets1981 · 31 citations
  4. 4Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.1998 · 264 citations