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May 24, 2017Thrombosis and HaemostasisOpen Access

Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions

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Population

Whole human blood

Design

Preclinical

Authors

NPNicholas PughSouth Dakota School of Mines and TechnologyBMBen MaddoxUniversity of CambridgeDBDominique BihanUniversity of Calgary

Discussion

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Implication

Should not change clinical practice; leaves open the potential for targeting synergistic platelet receptor pathways.

Structured PICO

P
Population
Whole human blood
I
Intervention
Collagen or combinations of receptor-specific collagen-mimetic peptides
O
Outcome
Real-time and endpoint parameters of thrombus formation alongside [Ca2+]i measurements using confocal imagingsurrogate

Platelet receptors α2β1, GpIb/V/IX, and GpVI synergize to generate intracellular calcium signals that regulate platelet behavior and thrombus formation under arterial flow conditions.

Cite This Study

Pugh et al. (2017) studied this question.

synapsesocial.com/papers/6a8812273fe66a1452bbfaf6https://doi.org/10.1160/th16-12-0906

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet collagen receptor integrin α2β1activation involves differential participation of ADP‐receptor subtypes P2Y1 and P2Y12 but not intracellular calcium change2001 · 47 citations
  2. 2P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions2010 · 99 citations
  3. 3Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombosis2009 · 437 citations
  4. 4Platelet-collagen interaction: is GPVI the central receptor?2003 · 1,164 citations
  5. 5Transmembrane Calcium Influx Associated with von Willebrand Factor Binding to GP Ib in the Initiation of Shear-Induced Platelet Aggregation1993 · 163 citations