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August 6, 2016Journal of Cell Science

Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling

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Population

Megakaryocytes (lacking collagen receptors or treated with blocking antibodies)

Comparison

Collagen type I exposure and GPVI receptor… vs Other collagen types or untreated/wild-type…

Design

Preclinical

Authors

DSDaniela SemeniakRKRebecca KulawigDSDavid Stegner

Discussion

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Overview

May refine models of marrow platelet release; leaves open whether GPVI targeting affects thrombopoiesis in vivo.

Structured PICO

P
Population
Megakaryocytes (lacking collagen receptors or treated with blocking antibodies)
I
Intervention
Collagen type I exposure and GPVI receptor manipulation (blocking antibodies or genetic deletion)
C
Comparator
Other collagen types (e.g., collagen IV) or untreated/wild-type megakaryocytes
O
Outcome
Proplatelet formation (PPF) and signaling pathway activationsurrogate

Collagen type I selectively inhibits proplatelet formation via a Syk-independent GPVI signaling pathway, providing mechanistic insight into how premature platelet release is prevented in the bone marrow.

Cite This Study

Semeniak et al. (2016) studied this question.

synapsesocial.com/papers/6a6f5c7384cc45bb7bdf9d2dhttps://doi.org/10.1242/jcs.187971
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet-collagen interaction: is GPVI the central receptor?2003 · 1,163 citations
  2. 2Integrin α2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen2002 · 268 citations
  3. 3Identification of Shc as the Primary Protein Binding to the Tyrosine-phosphorylated β3 Subunit of αIIbβ3 during Outside-in Integrin Platelet Signaling2000 · 92 citations
  4. 4Immunofluorescence Characterization of Key Extracellular Matrix Proteins in Murine Bone Marrow In Situ1998 · 183 citations
  5. 5Dynamic Visualization of Thrombopoiesis Within Bone Marrow2007 · 646 citations