Key result
Syk inhibition with PRT-060318 suppressed platelet activation and aggregation on collagen-like structures, indicating GPVI-dependent signaling through Syk supports thrombus formation.
Why the study?
To determine the Syk-mediated thrombogenic activity of several collagen peptides and fibrillar type I and III collagens.
Does Syk inhibition with PRT-060318 reduce thrombus formation on collagen-like surfaces in whole blood and platelet suspensions?
Population
Whole blood and platelet suspensions
Comparison
Syk inhibitor PRT-060318 vs control across various collagen surfaces
Design
In vitro experimental perfusion study
Authors
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Syk inhibition may attenuate thrombus formation in preclinical models; leaves open translation to human antithrombotic therapy.
Does Syk inhibition with PRT-060318 reduce thrombus formation on collagen-like surfaces in whole blood and platelet suspensions?
GPVI-dependent signaling through Syk supports platelet activation in thrombus formation on collagen-like structures regardless of the presence of a (GPO)n sequence.
Jooss et al. (2019) studied Thrombus formation. Syk inhibitor PRT-060318 was evaluated on Thrombus formation (platelet adhesion, activation, aggregation, and contraction). Syk inhibition with PRT-060318 suppressed platelet activation and aggregation on collagen-like structures, indicating GPVI-dependent signaling through Syk supports thrombus formation.
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