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March 1, 1975American Journal of Physiology-Legacy Content

Relation between length, isometric force, and O2 consumption rate in vascular smooth muscle

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Population

Bovine mesenteric vein

Comparison

Epinephrine stimulation at varying lengths vs Basal state (unstimulated) or varying lengths

Design

Preclinical

Authors

RPR J PaulPaul HastingsJPJ. W. PetersonHeidelberg University

Discussion

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Implication

Supports sliding-filament model in vascular smooth muscle; leaves open translation to human cardiac energetics.

Structured PICO

P
Population
Bovine mesenteric vein
I
Intervention
Epinephrine (2-5 mug-ml-1) stimulation at varying lengths
C
Comparator
Basal state (unstimulated) or varying lengths
O
Outcome
Length-tension and length-oxygen consumption rate relationshipssurrogate

In bovine mesenteric vein smooth muscle, the length dependence of active isometric force and chemical energy utilization are parallel, supporting a sliding-filament model.

Cite This Study

Paul et al. (1975) studied this question.

synapsesocial.com/papers/6a6fa217f44fa9f079dd1952https://doi.org/10.1152/ajplegacy.1975.228.3.915
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The active tension-length curve of vascular smooth muscle related to its cellular components.1979 · 143 citations
  2. 2Length at Inactivated Contractile Elements, Length‐tension Diagram Active State and Tone of Vascular Smooth Muscle1966 · 66 citations
  3. 3Control of myocardial oxygen consumption: relative influence of contractile state and tension development1968 · 276 citations
  4. 4Some factors influencing O2 consumption of isolated heart muscle1960 · 31 citations
  5. 5Indices of myocardial oxygen consumption for isotonic contraction1979 · 2 citations