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June 29, 2006Journal of Medicinal ChemistryOpen Access

Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90

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JGJie GeAir Force Medical UniversityENEmmanuel NormantUniversitat Autònoma de BarcelonaJPJames R. PorterBoston College

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Ge et al. (2006) studied this question.

synapsesocial.com/papers/6a6fa28526a7f98052dc4368https://doi.org/10.1021/jm0603116
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.1994 · 1,451 citations
  2. 2Unusual expression and localization of heat‐shock proteins in human tumor cells1992 · 437 citations