This article describes fabrication of a two-component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen-alginate ECM, reversible crosslinking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen matrix (the structural component).
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Gillette et al. (2009) studied this question.
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