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March 1, 1984Proceedings of the National Academy of Sciences

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

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Authors

ENEric M. NelsonJohns Hopkins UniversityKTK M TeweyHarvard UniversityLLLeroy F. LiuRutgers, The State University of New Jersey

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Nelson et al. (1984) studied this question.

synapsesocial.com/papers/6a6fa31f75498292b70903fahttps://doi.org/10.1073/pnas.81.5.1361
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DNA Gyrase and the Supercoiling of DNA1980 · 719 citations
  2. 2Cell-Cycle-Specific Chromosome Damage Following Treatment of Cultured Chinese Hamster Cells With 4′-[(9-Acridinyl-amino] methanesulphon-m-anisidide-HCl21978 · 55 citations
  3. 3DNA Topoisomerases1981 · 989 citations
  4. 4Cleavage of DNA by mammalian DNA topoisomerase II.1983 · 537 citations