Why the study?
Does ACC2 mutation alter myocardial substrate oxidation and cardiac function in mice?
Population
Male Acc2-mutant transgenic mice and wild-type controls, aged 5 months or 31 weeks.
Comparison
Genetic mutation of acetyl-CoA carboxylase 2 vs Wild-type (WT) mice
Design
Preclinical, The same person obtained all images and measures and was blinded…
Authors
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ACC2 mutation reduces LV mass with preserved function in mice; hypothesis-generating for ACC2 inhibition in human cardiomyopathy.
Does ACC2 mutation alter myocardial substrate oxidation and cardiac function in mice?
ACC2 mutation in mice leads to reduced heart size with preserved contractile function, driven by increased myocardial oxidation of both glucose and fatty acids.
Essop et al. (2008) studied this question.
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