Why the study?
The electrophysiological events occurring immediately after traumatic brain injury that may underlie impact outcomes have not been fully elucidated.
In a rat model of traumatic brain injury, cortical and brainstem spreading depolarizations occur immediately after impact and are associated with altered oxidative stress and mortality in severe cases.
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Immediate spreading depolarizations post-TBI in rats require human validation; leaves open their role in clinical outcomes.
Aboghazleh et al. (2021) studied this question.
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