Why the study?
SARS-CoV-2 effects are not always acute or confined to respiratory systems, and emerging evidence challenges the view that its lifecycle is strictly cytoplasmic without affecting the host cell nucleus.
Population
Host cells infected with SARS-CoV-2
Design
Review
Authors
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Hypothesis-generating for non-cytoplasmic SARS-CoV-2 effects in Long COVID; leaves open replication paradigms for rigorous validation.
This review highlights that SARS-CoV-2 is not confined to the cytoplasm but can interact with the host cell nucleus, potentially explaining the chronic inflammation seen in Long COVID.
Laura Lafon-Hughes (2023) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: