Why the study?
As extracellular vesicles gain attention as targeted gene carriers, their effects on the host immune response and their role in the anti-inflammatory effects triggered by physical exercise warrant review.
Circulating extracellular vesicles may mediate the anti-inflammatory effects of physical exercise by regulating the host immune response.
Extracellular Vesicles (EVs) are circulating particles surrounded by a plasma membrane carrying a cargo consisting of proteins, lipids, RNAs, and DNA fragments, stemming from the cells from which they originated. EV factors (i.e., miRNAs) play relevant roles in intercellular crosstalk, both locally and systemically. As EVs increasingly gained attention as potential carriers for targeted genes, the study of EV effects on the host immune response became more relevant. It has been demonstrated that EVs regulate the host immune response, executing both pro- and anti-inflammatory functions. It is also known that physical exercise triggers anti-inflammatory effects. This review underlines the role of circulating EVs as players in the anti-inflammatory events associated with the regulation of the host's immune response to physical exercise.
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Catitti et al. (2022) studied this question.
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